The industry is fragmented and extends from small, privately owned companies to divisions of big, diversified chemical enterprises. The term “fine chemicals” is used in distinction to “heavy chemicals”, which are produced and handled chemical reactor analysis and design solution manual pdf large lots and are often in a crude state. Since their inception in the late 1970s, fine chemicals have become an important part of the chemical industry.
40 among in-house production by the main consumers, the life science industry, on the one hand, and the fine chemicals industry on the other hand. The products are mainly used as building blocks for proprietary products. The hardware of the top tier fine chemical companies has become almost identical. The design, lay-out and equipment of the plants and laboratories has become practically the same all over the world.
Most chemical reactions performed go back to the days of the dyestuff industry. Numerous regulations determine the way labs and plants have to be operated, thereby contributing to the uniformity. Switzerland, which already had supplied an early intermediate, methyl acetoacetate, during drug development, soon became the main supplier of more and more advanced precursors. The signature of a first, simple supply contract is generally acknowledged as the historical document marking the beginning of the fine chemical industry.
H2 receptor antagonist, marketed as Zantac by Glaxo. Other pharmaceutical and agrochemical companies gradually followed suit and also started outsourcing the procurement of fine chemicals. For many years, however, the life science industry continued considering captive production of the active ingredients of their drugs and agrochemicals as a core competency. In the production of modern life science products, total synthesis from petrochemicals prevails. The HMW products, respectively large molecules, are obtained mainly through biotechnology processes.